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Fever of unknown origin7/26/2023 Consult ophthalmology for fundoscopic evaluation.See “ Differential diagnoses of fever by associated finding.”.See “ Differential diagnoses of fever by risk factors.”.Identify hallmarks or diagnostic clues.Consider discontinuing nonessential drugs to exclude drug fever.Conduct serial physical examinations (see “Focused examination” in “ Fever” and “ Differential diagnosis of fever by course”).Document contact with animals, travel history, diet history, immunosuppression, family history, social and sexual history, occupational history, drugs and medications, implants, catheters, and grafts (see “Focused history” in “ Fever ”).Perform a comprehensive clinical evaluation.The evaluation of a patient with FUO should proceed in a stepwise fashion, guided by diagnostic clues obtained from the history and physical examination. In people living with HIV, also consider HIV-associated conditions (e.g., Pneumocystis pneumonia, MAC infection, Kaposi sarcoma) and immune reconstitution inflammatory syndrome.
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